People who have undergone a liver transplant are at a three-fold risk of developing cancer than the general population, according to researchers. The research team led by Helena Isoniemi of Finland analyzed cancer risk pattern in Finnish liver transplant patients from Helsinki University Central between 1982 and 2005.
Among the 540 liver transplant recipients, they found a total of 39 post-transplant de novo cancers in 36 patients.
The overall standardized incidence ratio (SIR) compared to the general population was 2.59. Non-Hodgkin lymphoma, non-melanoma skin cancer and basal cell carcinoma had significantly elevated SIRs.The most common cancer types in human cohort are lymphoma and skin cancer.
"Non-Hodgkin lymphoma, which included four cases of post-transplant lymphoproliverative disorder, occurred more frequently in males, in patients transplanted at a younger age and soon after transplantation."
Whereas, non-melanoma skin cancer was more common among older patients and those who had antibody induction therapy.
It has been noted a significantly increased risk of de novo oropharyngeal and lung cancers amongst liver transplant patient
s that smoke, which a potentially preventable condition is."The overall rate of de novo solid tumors increased with age at the time of transplant and the length of follow up; while the rate of post-transplant lympho-proliferative disorders decreased with age at the liver transplant, with a higher incidence in the first few years,” as by research.
The study appears in Liver Transplantation, is available in a journal by John Wiley and Sons.
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